Paul Ramsey, Daniel  Linden, and David E. Anderson.
Dept. of Veterinary Clinical Sciences
College of Veterinary Medicine
The Ohio State University
Columbus, Ohio 43210

      There are currently no Clostridial vaccines (7 or 8-way) on the
market labeled for specific use in llamas and alpacas and a wide variety of
vaccines are made by a multitude of different manufacturers.  Feedback from
owners and veterinarians indicate significant variability in vaccine
reaction rates in llamas and alpacas.  We hypothesized that there would be
a marked difference different vaccine manufacturers in terms of vaccine
reaction severity.  This project was designed to examine the size and
frequency of vaccine site reaction of 6 different 7-way and 7 different
8-way Clostridial vaccines by different manufactures.  The vaccine dosage
was administered at the manufacture's recommended sheep dosage or, when a
sheep dosage was not available, the cattle dosage was used.  Following the
injection of these vaccines, the height and width of the reaction sites
were measured on Day 2, 7, 14, and 28. Analysis of graphs of the means of
the reaction sites, the BarVac 7 vaccine caused the smallest vaccine site
reactions among the other Clostridial 7-way vaccines. The Agrilabs 8
vaccine caused the smallest size of reactions on average among the
Clostridial 8-way vaccines.  Although the results of this study suggest
that either BarVac 7 or Agrilab 8 would be preferred for clinical use, the
relative efficacy of these vaccines to stimulate antibody production was
not evaluated.  This information is needed before a final recommendation
can be made.

For those interested in helping fund continuing research into vaccinology
of camelids, tax-deductible contributions may be sent to the "Camelid
Research Fund", c/o Susan Kelly, Veterinary Teaching Hospital, 601 Vernon L
Tharp Street, Columbus, Ohio 43210.

David E Anderson, DVM, MS
Diplomate, American College of Veterinary Surgeons
Associate Professor of Surgery, Food Animal
601 Vernon L Tharp Street
College of Veterinary Medicine
The Ohio State University